孤立性肺结节双源CT灌注成像与微血管构成的相关性研究

项目名称： 孤立性肺结节双源CT灌注成像与微血管构成的相关性研究

项目编号： No.81460265

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 李邦国

作者单位： 遵义医科大学

项目金额： 47万元

中文摘要： 孤立性肺结节（SPN）是一种常见的放射学征象。SPN的诊断和鉴别诊断是肺癌早诊早治的关键。CT灌注成像（CTPI）在肿瘤的定量、定性研究中有重要价值。既往研究显示，良性、恶性SPN的CT灌注参数之间具有显著性差异，但是恶性、炎性SPN的CTPI表现常存在重叠，鉴别诊断困难；SPN的多项CT灌注参数与MVD具相关性，但是良性、恶性SPN的MVD之间无统计学差异。近年来，通过免疫组化对肿瘤血管生成的研究发现，良性、炎性及恶性SPN的微血管腔成熟度不同。根据大量文献和申请人的工作积累，炫速双源CT在辐射防护、扫描速度、灌注参数种类及灌注图像质量等具有明显优势，有利于开展SPN的CT灌注成像研究。本项目拟引入有腔血管参数来定量分析SPN的微血管构成，并与SPN的炫速双源CT灌注参数对比分析，为探究不同性质SPN的CTPI特点提供较为客观的理论依据，有助于SPN的诊断与鉴别诊断。

中文关键词： 孤立性肺结节；体层摄影术；X线计算机；灌注成像；血管生成；有腔血管

英文摘要： Solitary pulmonary nodules(SPN) is a common radiological signs, which is key to early diagnosis and treament of lung cancer. CT perfusion imaging(CTPI) has the significant value in the quantitative and qualitative research of tumor. Previous studies showed that there are significant differences between CT perfusion parameters of benign SPNs and malignant SPNs. However, CTPI findings of malignant SPNs and inflammatory SPNs are often overlapping, differential diagnosis is difficult. There is a relationship between CT perfusion parameters and microvessel density(MVD) in SPNs, but no statistical differences between benign SPNs and malignant SPNs in MVD. In recent years, the immunohistochemical study of tumor angiogenesis found that the maturity of microvessel was different among benign SPNs, malignant SPNs and inflammatory SPNs. According to a large number of recent documents and our studies,flash dual source computed tomography has obvious advantages in radiation protection technology, scanning speed, perfusion parameter types, perfusion image quality,etc. It is conducive to the study of CTPI in SPN.In the present project, We plan to introduce luminal vascular parameters to do a quantitative analysis of the microvascular structure in SPN, and perform a comparative analysis with flash dual source CT perfusion parameters of SPN, and provide a more objective theoretical basis for exploring CTPI characteristics of SPNs.This is helpful for the diagnosis and differential diagnosis of SPNs.

英文关键词： solitary pulmonary nodule;tomography;X-ray computed;perfusion imaging;angiogenesis;luminal vessel