生物耐蚀抗菌性的镁合金表面的多层分子组装

项目名称： 生物耐蚀抗菌性的镁合金表面的多层分子组装

项目编号： No.21273142

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 陈亚芍

作者单位： 陕西师范大学

项目金额： 82万元

中文摘要： 本研究基于多基元组分复合在镁合金表面构建多功能性组装分子层，以解决镁合金医用材料耐腐蚀性和抗菌性较差等难题。利用等离子体技术分别构建钙二氧化硅及植酸等耐腐蚀性分子层，通过抗腐蚀性能差异性比对，揭示组成、结构与性能的关系；以点击化学反应或超分子作用分别以聚乙二醇及聚磷酰胆碱为连接臂，将葫芦脲及其衍生物以端基化或串珠式连接于目标材料表面以负载纳米银；通过葫芦脲及其衍生物不同结合形式对银离子络合作用差异性研究，揭示其结构对纳米银粒径及缓释性能的影响规律；通过葫芦脲及其衍生物与不同连接臂间的相互作用研究，揭示连接臂对表面组装葫芦脲及其衍生物稳定性的影响规律；通过不同组成与结构特征组装体系的生物腐蚀性、抗菌性、生物相容性研究，揭示镁合金表面组装分子层组成及结构与耐蚀性、抗菌性间的关联性，以及生物耐蚀性和抗菌性双效功能的协同作用规律。该研究工作将为医用金属材料表面多功能化的组装设计提供新的技术和方法。

中文关键词： 镁合金；多分子层组装；耐腐蚀性；生物相容性；抗菌性

英文摘要： In this project, multifunctional molecular multilayers are constructed on surface of Mg alloy to overcome issues of its poor biocorrosion resistant and antibacterial performance. Plasma technology is used to fabricate anticorrosive Ca-SiO2 and phytic acid (PA) layers, and the relationship between composition, structure of the layers and anticorrosive performance is expected to reveal. cucurbit[8]uril (CB[8]) and its derivatives loaded with Ag nanoparticles (AgNPs) are connected on Mg alloy substrate in the forms of terminal and bead-type, based on the immobilisation of biocompatible spacer molecule - poly(ethylene glycol) (PEG) and 2-methacryloxyethyl phosphorylcholine polymer (PMPC), click reaction and supramolecular host-guest interaction. Different conjugate ways of CB[8] (and its derivatives) are desired to affect their complexing action to Ag+ and the size of AgNPs as well as its release property. Effects of various linkers on stablity of CB[8] (and its derivatives) are anticipated to reveal by study of the interaction between them. Based on biocorrosion resistant, antibacterial properties and biocompatibility of different assembly systems, the relationship between composition, structure of multilayer molecular on Mg alloy and anticorrosive, antibacterial performances, including the synergism of these two k

英文关键词： Magnesium alloy；multi-molecular films assembly；Corrosion resistance；Biocompatibility；Antibacterial property