钛基生物材料微图形多功能生物活性表面与人体血液及内皮细胞的相互作用机制与调控

项目名称： 钛基生物材料微图形多功能生物活性表面与人体血液及内皮细胞的相互作用机制与调控

项目编号： No.31470926

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 生物科学

项目作者： 潘长江

作者单位： 淮阴工学院

项目金额： 90万元

中文摘要： 钛基生物材料在血管支架、血栓滤器等血管内介入医疗器械方面具有广泛的应用，通过表面改性赋予材料多功能生物活性，使其具有对血液、周围组织、细胞进行生物调控的能力，对增强材料的性能和功能具有十分关键的科学意义。本项目以材料与血液及内皮细胞的界面相互作用为切入点，充分考虑材料表面的多功能生物化学活性以及材料表面的拓扑形貌结构对材料性能和功能的影响，采用微接触印刷术结合其它表面改性技术在钛基生物材料表面构建微图形多功能生物活性表面，研究表面生物活性分子及其分布的拓扑结构对血液及内皮细胞行为的影响规律，探明材料与血液及内皮细胞的相互作用机制及其调控机理。通过本项目的研究，将在调控材料表面多种生物功能、调控材料表面的细胞形态与功能等方面取得进一步认识，并建立起钛基生物材料多功能生物活性表面改性的关键技术，获得具有优异性能和功能的钛基血管内植入材料。

中文关键词： 表面改性；血液相容性；钛；内皮细胞；微图形

英文摘要： Titanium-based biomaterials have been widely used for intravascular interventional medical devices such as stent and thrombosis filter. Surface modification plays a key scientific role in improving the performances and functions of materials by providing multi-functional bioactivities and the ability to regulate blood, surrounding tissues and cells. Fully considering the influences of multi-functional biochemical activities and topographical structures of materials surface on their performances and functions, this project is established on the interfacial interactions between materials and blood and endothelial cells, microcontact printing combined with other surface modification techniques are used to create the micropatterned multifunctional bioactive surface on titanium-based biomaterials surface. The effect rules of surface bioactive molecules and the topographical structures of their distribution on blood and endothelial cell behaviors will be studied. The interaction and regulation mechanism between materials and blood and endothelial cell will be clarified. By this project, how to regulate surface multiple biological functions and surface cell morphologies and functions and so on will be further understood. The key multi-functional bioactive surface modification techniques of titanium-based biomaterials will be established and the titanium-based intravascular implant materials with excellent performances and functions will be obtained.

英文关键词： surface modification;blood compatibility;titanium;endothelial cell;micropattern