Chemerin通过P38MAPK途径介导糖尿病肾病及硫辛酸干预研究

项目名称： Chemerin通过P38MAPK途径介导糖尿病肾病及硫辛酸干预研究

项目编号： No.81202189

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 预防医学、地方病学、职业病学、放射医学

项目作者： 张慧娟

作者单位： 哈尔滨医科大学

项目金额： 24万元

中文摘要： 糖尿病肾病是糖尿病最主要的微血管并发症，是威胁公众健康的重大问题。最近有研究表明新发现的脂肪因子chemerin可能与糖尿病肾病的发生发展相关。另外，硫辛酸作为一种抗氧化营养素，在糖尿病肾病中的保护作用也越来越受到关注。最近研究提示chemerin引起的炎症损伤可能与P38MAPK信号通路有关，我们的前期工作观察到chemerin及其受体在糖尿病大鼠肾脏中表达增加，初步证明了chemerin与糖尿病肾病的相关性，但确切的作用机制尚不清楚。在前期工作基础上，本项目将通过体内及体外实验，分别从基因及蛋白水平求证chemerin对糖尿病肾病P38MAPK及其下游NF-κB信号通路相关的炎症因子的影响作用，以及硫辛酸干预对以上影响的抑制作用，以期寻求预防及治疗糖尿病肾病的新靶点。

中文关键词： chemerin；糖尿病肾病；P38MAPK信号通路；硫辛酸；

英文摘要： Diabetic nephropathy is the most main microvascular complications of diabetes, which is a major threat to public health. Adipokine chemerin, a novel adipocyte-secreted factor was implicated in diabetic nephropathy progression. However, the precise mechanism of diabetic nephropathy by adipokine chemerin in diabetes has not been clarified. On the other hand, lipoic acid, an antioxidant has been attracting particular attention because of the protective effect on diabetic nephropathy. Recently, chemerin and lipoic acid were shown to be associated with p38 Mitogen-activated protein kinase-fibronectin (P38MAPK) signal pathway and inflammation in diabetic nephropathy. In contrast to the established role of chemerin and lipoic acid in P38MAPK signal pathway or inflammation, its molecular mechanisms remain elusive. Previously, we have found that chemerin and its receptor was observed to be higher expressed in kidney of diabetic rats, which preliminarily proved the correlation between chemerin and diabetic nephropathy. On this basis, this project will provide insights into the link between chemerin, p38MAPK, NF-κB signal pathway and inflammation through vivo and vitro experiments; lipoic acid intervention will be also involved in this study. Furthermore, we will explore its possible molecular mechanisms that can lead to

英文关键词： chemerin；diabetic nephropathy；P38MAPK signaling pathway；lipoic acid；