稳态强磁场下可视化脊椎动物的神经发育和神经功能研究

项目名称： 稳态强磁场下可视化脊椎动物的神经发育和神经功能研究

项目编号： No.U1332136

项目类型： 联合基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 胡兵

作者单位： 中国科学技术大学

项目金额： 66万元

中文摘要： 随着磁共振成像（MRI）技术在临床上的广泛应用，人类接触稳态强磁场的几率大大增加。MRI使用的稳态磁场强度远高于地磁场，因此，稳态强磁场对正常人体潜在可能的负面作用得到广泛关注。已有的研究多在小于10.0T的稳态磁场下进行，很多侧重于强磁场对生物个体水平的影响，专门研究磁场对神经系统发育和功能的不多，且结果多有争议。此外，由于MRI常用于妊娠检测，尤其是对胎儿大脑进行宫内检测，研究稳态强磁场对神经发育的影响就很有意义。利用我们已经建立的脊椎模式动物斑马鱼和非洲爪蟾可视化研究的独特优势，我们着力于探究稳态强磁场对胚胎发育，尤其是神经发育和神经功能的影响，试图在宏观的行为学层面观察稳态强磁场作用于该模式动物神经功能的效应，并进一步在微观的细胞层面上深入理解稳态强磁场对神经生长、突触发育以及神经再生的机制。总而言之，在探究稳态强磁场可能的负面影响的同时，也发掘其在神经科学领域的新应用。

中文关键词： 稳态强磁场；神经发育；神经功能；斑马鱼；爪蛙

英文摘要： With the wide clinical application of magnetic resonance imaging (MRI), people have an increasing chance to be exposed to static high magnetic field (SHMF). As the intensity of the static magnetic field used in MRI is much stronger than geomagnetic field, the potential adverse effects of SHMF receive more and more attention. Most of the previous researches are carried out under 10T or lower magnetic fields, and many concentrate on the biological effects of SHMF at individual level. Only a few study the effects on neurodevelopment and often get inconsistent results. Moreover, as MRI is frequently used in pregnancy detection, especially the detection of fetus brain in utero, it’s meaningful to study the effects of SHMF on neurodevelopment. Taking full advantage of the established visualized study of vertebrate model organism zebrafish and Xenopus, we strive to explore the effects of SHMF on embryonic development, especially on neurodevelopment and neural functions. On the context of SHMF, we would like to study the neural functions at behavioral level and elucidate the mechanisms of neural growth, synaptogenesis and neuronal regeneration at cellular level. In conclusion, besides the potential adverse effects, we also try to explore the new applications of static high magnetic field in neuroscience.

英文关键词： static high magnetic fields；neurodevelopment；neural functions；zebrafish；xenopus