延长觉醒对大鼠前额叶皮层神经元活动的影响及机制研究

项目名称： 延长觉醒对大鼠前额叶皮层神经元活动的影响及机制研究

项目编号： No.30800450

项目类型： 青年科学基金项目

立项/批准年度： 2009

项目学科： 生物科学

项目作者： 夏建霞

作者单位： 中国人民解放军第三军医大学

项目金额： 20万元

中文摘要： 随着社会的快速发展和生活压力的增大，人们不得不以牺牲睡眠为代价获取更多的工作时间。然而，这种延长觉醒是如何发生的，及长时程延长觉醒会否影响大脑皮层功能迄今所知甚少。本项目拟选择前额叶皮层深层（IV－V）锥体神经元为对象，采用微透析、神经电生理、形态学和分子生物学等技术，就延长觉醒时前额叶皮层神经元对皮层下觉醒系统兴奋性输入反应性的变化，及各皮层下觉醒系统突触可塑性的改变等方面的问题进行研究，以期通过阐明延长觉醒情况下，皮层下觉醒系统输入和前额叶皮层神经元反应性变化，进一步深入理解皮层下觉醒系统与皮层面对强迫觉醒所产生适应性变化规律。

中文关键词： 延长觉醒；前额叶皮层；皮层下结构；突触可塑性；适应

英文摘要： Abundant evidence have demonstrated that prolonged wakefulness will influence many of physiological functions of human, such as attention, learning and memory, neuroendocrine and autonomic functions, as well as the sleep-wakefulness. It has been shown that stress blunts evoked excitatory transmission in prefrontal cortex. Little is known about the changes of activities of prefrontal cortex and synaptic plasticity of subcortical arousal systems under the prolonged-wakefulness condition as a stress. The purpose of this project is to observe the adaptive changes of activities of prefrontal cortex and synaptic plasticity of subcortical arousal systems under the prolonged-wakefulness condition, which will provide more evidence for better understanding the activities of arousal systems in sleep-wakefulness cycle.

英文关键词： prolonged-wakefulness；prefrontal cortex；subcortical；synaptic plasticity；adaptation