慢性萎缩性胃炎藏医证型分类与生物标记的相关性研究

项目名称： 慢性萎缩性胃炎藏医证型分类与生物标记的相关性研究

项目编号： No.81460768

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 仁青东主

作者单位： 青海大学

项目金额： 45万元

中文摘要： 慢性萎缩性胃炎（CAG）是高原地区最常见的一种消化道疾病，藏医称为普如病，属于剑突培根病、胃铁锈症、胃衰症等培根疾病范畴。其发病率在高原地区相对较高，随年龄增长而升高的趋势，具有很高的癌变率，被列为胃癌前主要疾病之一。 藏医药对CAG的疗效取得了良好的效果，积累了丰富的经验，发挥着藏医药的优势和特色。但藏医界对该病的证型分类方面有着不同的看法，这对进一步深入研究CAG的诊疗标准起着很大的阻碍。为了规范化藏医对CAG的认识，确定证型和证候分布规律，对制定CAG的诊断标准化提供科学依据。本课题将依据藏医诊断三诊（望、切、闻）辩证理论，采用文献调研、专家咨询、流行病学、检验方法，搜集300多名患者的体征、症状、以及相关的生物标记，对这些临床信息与检验指标的对应性进行数理统计。研究CAG的藏医证型，与临床证候和相关性生物标记的分布规律，对藏医药学现代化的进程将起到重要作用。

中文关键词： 慢性萎缩性胃炎；藏医；证型；生物标记

英文摘要： The goals of this project are to differentiate syndrome types, and facilitate early detection and early diagnosis of chronic atrophic gastritis (CAG). CAG is a commonly-occuring disease in the digestive system.Western medical literature has reported that incidence increases by age and high altitude exposure, and is linked to Helicobacter pylori infection. In Tibetan medicine, it is called phori gastric disease, and affliates with badkan disease. The disease is highly prevalent among Tibetan populations, and is listed as one of the common precancerous lesions among gastric diseases on the Tibetan plateau. From empirical evidence, Tibetan medicine has demonstrated high effectivity in the prevention and treatment of CAG. Tibetan medical theoretical foundations and accumulated clinical experiences detail the distinctly unique treatment protocol, approach and medicine regiment for this gastric disease. However, differentiating syndrome types of chronic atrophic gastritis engenders significant dispute among physicians in the Tibetan medical field, which, consequently, hinders the establishment of a national standardized set of diagnostic criteria for each syndrome. This project will be based on Tibetan medical diagnostics, such as sphygmology, tongue analysis and patient query methods. Additionally, it will employ Western scientific methods, such as Delphi consultation methods, epidemiological analysis, and serum laboratory tests. This study will recruit at least 300 CAG patients with clinical symptoms, gastroscopic data, blood and urine laboratory biomarkers and other disease-related patient data. Then the study will statistically analyze the collected biomarkers and clinical data and examine the correlations between the Tibetan medical phori syndrome types and diagnostic assessments of chronic altrophic gastritis with the associated biological markers (e.g., Helicobacter pylori presence, serum gastrin G17, pepsinogen I, II) for each syndrome. Ultimately, the study will provide a basis for establishing correlations between the Tibetan medical and Western medical diagnostic criteria for each syndrome type for the more effective clinical diagnosis and treatment of chronic atrophic gastritis in the future. Through uncovering the relationships between syndrome types and biomarkers, this study is the first of its kind to offer scientific and measurable criteria for Tibetan medical diagnosis. This model study can promote the integratation of Western and Tibetan medicine, facilitate Tibetan medical modernization, and create a new era for studying clinical disease in Tibetan medicine.

英文关键词： Chronic Atrophic Gastritis;Tibetan medicine;syndrome;biomarker