从流变性和表面粘附能探索聚合物水凝胶粘接机理及预测粘接性

项目名称： 从流变性和表面粘附能探索聚合物水凝胶粘接机理及预测粘接性

项目编号： No.51273063

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 一般工业技术

项目作者： 郭旭虹

作者单位： 华东理工大学

项目金额： 80万元

中文摘要： 本项目设计合成三种生物相容性聚合物水凝胶黏合剂，并以其为模型体系系统研究黏合剂流变性和表面粘附能对粘接性能的影响规律，探索粘接机理。首先采用环糊精改性聚丙烯酸与长链烷基改性聚丙烯酸在水溶液中混合，利用环糊精与长链烷基的包合作用加上长链烷基间的疏水缔合制备水凝胶黏合剂。其次利用丙烯酸和甲基丙烯酸（具有温敏性）在纳米粘土粒子表面的原位自由基聚合制备纳米复合聚合物水凝胶黏合剂。此外，通过化学交联制备聚丙烯酸、聚甲基丙烯酸及丙烯酸和丙烯酰胺共聚物水凝胶黏合剂。采用流变学方法研究凝胶过程的变化规律，尤其是凝胶点附近弹性模量和粘性模量随频率变化趋势与粘接性能的关联。采用自制的表面能测量仪（JKR仪）定量测得聚合物水凝胶的表面粘附能和模量，并研究其与粘接性能的关联。首次结合流变性和表面粘附能来揭示聚合物水凝胶的粘接机理，预测其粘接性，为其在假牙黏合剂、伤口覆敷、组织工程、透皮给药等领域的应用奠定基础。

中文关键词： 水凝胶；粘结性能；流变性能；表面粘附能；仿生

英文摘要： There biocompatible polymeric hydrogels will be designed and prepared, and used as model systems to explore the effect of rheology and surface adhesive energy of polymeric hydrogels on their adhesion as well as the adhesive mechanism. First, polymeric hydrogel adhesives based on cyclodextrin inclusive association by mixing the aqueous solution of cyclodextrin modified poly(acrylic acid) (PAA) and long chain alkyl modified PAA will be formed. Then, hybrid polymeric hydrogels will be prepared by in-situ polymerization of acrylic acid or methacrylic acid (thermosensitive) on the surface of nano-sized clay particles. Finally, chemically crosslinked PAA, poly(methacrylic acid) or the copolymer of acrylic acid and acrylamide hydrogels will be synthesized. Rheology will be employed to study the gelation process, especially the correlation between adhesion and the elastic modulus G' and the viscous modulus G" as a function of the frequency. Home-made surface energy apparatus (JKR apparatus) will be used to determine the surface adhesive energy and Young's modulus of polymeric hydrogels. The correlation between the surface adhesive energy and adhesion of polymeric hydrogels will be discussed. This is the first time to explore the adhesive mechanism and forecast the adhesion of polymeric hydrogels based on both rheology

英文关键词： Hydrogel；Adhesion；Rheology；Surface adhesive energy；Biomimic