环糊精功能化量子点光学传感体系构筑及其手性农药分子识别与残留研究

项目名称： 环糊精功能化量子点光学传感体系构筑及其手性农药分子识别与残留研究

项目编号： No.21507076

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 化学工业

项目作者： 卫艳丽

作者单位： 山西大学

项目金额： 21万元

中文摘要： 表面化学修饰不仅可以提高量子点的稳定性及分散性，还可进一步改善其光学性质。本项目拟采用水相合成法，以β-环糊精为保护剂，设计合成掺杂ZnS水性量子点纳米材料，利用其优良的光学特性，结合环糊精的独特的手性空穴，并通过第三组分小分子空间调节作用，增大分子相互作用差异，构建比率荧光光学传感，实现对手性农药对映异构体分子手性识别功能，进一步探索手性识别机理。在此基础上，以吩噻嗪和罗丹明类染料分子为荧光共振能量转移（FRET）受体对模型化合物，进行ZnS量子点- 染料FRET体系研究，对影响FRET效率的各种因素进行详细考察，优化实验条件，构筑高效的量子点-染料FRET体系，实现手性农药分子食品残留的简便、灵敏、快速识别。环糊精独特的分子结构与量子点优良的光学特性相结合，对于提供农产品食源性预警信息具有潜在的应用价值。

中文关键词： 量子点；；手性识别；比率荧光；环糊精；手性农药残留

英文摘要： Surface chemical modification can not only enhance the stability and dispersion of the quantum dots, but also can further improve their optical properties. In this project, we’ll design and synthesize water-soluble doped ZnS quantum dots nano materials using beta-cyclodextrin as protecting agent by water-phase synthesis method, and construct the ratio fluorescence optical sensing system for chiral pesticides using its double fluorescence properties. On this basis, the interaction the molecular interaction differences is widen through a third small molecules as the space regulator in the chiral cavity of beta-cyclodextrin and then the chiral recognition of enantiomers is achieved. At the same time, we will further explore chiral recognition mechanism with the help of the nuclear magnetic resonance, infrared spectrum, circular dichroism, molecular mechanics calculation technology and so on. On this basis, ZnS quantum dots-dye FRET system will be fabricated using phenothiazines and rhodamine dye molecules as the fluorescence resonance energy transfer (FRET) receptor models. Various factors affected on FRET efficiency will be examined in order to construct high efficiency FRET system. Finally the fabricated FRET system will be applied to the chiral recognition of pesticide enantiomer molecules. And a simple, sensitive, rapid method for the chiral discrimination will be obtained. The unique molecular structure of cyclodextrin and the excellent optical characteristics of quantum exhibit a potential application in the early warning of agricultural commodities.

英文关键词： Quantum dots;chiral discrimination;ratoimetric fluorescence;cyclodextrin;chiral pesticide residue