通透性MR成像用于重度颅内动脉狭窄患者Ⅱ、Ⅲ级侧枝循环的定量评估

项目名称： 通透性MR成像用于重度颅内动脉狭窄患者Ⅱ、Ⅲ级侧枝循环的定量评估

项目编号： No.81501024

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 陈辉

作者单位： 中国人民解放军总医院

项目金额： 19万元

中文摘要： 颅内侧枝循环在缺血性脑卒中的发生、发展、治疗及预后中发挥着重要的作用，但目前没有可准确且定量检测Ⅱ、Ⅲ级侧枝循环的方法。我们前期工作发现通透性MR成像得到的Ktrans与重度颅内动脉狭窄病例的侧枝循环有较好的相关性，故提出假设：血脑屏障通透性（BBBP）反映了Ⅱ、Ⅲ级侧枝循环的变化，通过通透性MR定量检测BBBP可以间接得到远端侧枝循环的信息。我们将收集重度颅内动脉狭窄病例并评估其侧枝循环；以DSA为标准，比较各影像参数的差异，观察Ktrans是否能够稳定准确的定量评估Ⅱ、Ⅲ级侧枝循环；之后建立颅内动脉狭窄的动物模型，观察影像与病理之间的相关性，在病理水平上验证前期假设；拟建立一个基于通透性MR成像，能准确定量反映颅内远端侧枝循环状态的影像标志物。

中文关键词： 侧枝循环；颅内动脉狭窄；通透性核磁成像；血脑屏障

英文摘要： Cerebral collateral circulation plays an important role in the occurrence, treatment and prognosis of ischemic stroke. No imaging biomarker can satisfyingly evaluate the distal collateral circulation quantitatively. In our pilot study, there was good consistency between Ktrans and DSA in assessing the distal collateral circulation in the patients with severe intracranial arterial stenosis. We assumed Blood-Brain-Barrier Permeability(BBBP) was related to the distal collateral circulation, and we could achieve the information of distal circulation from the quantitative assessment with permeability imaging. We plan to select the patients with severe arterial stenosis, assess their cerebral collateral.circulation with different technique, compare the advantage and disadvantage of these techniques with DSA, and observe if Ktrans can be used to quantitatively evaluate the distal collateral circulation. We’ll establish animal model with intracranial arterial stenosis，assess the relevance between the image and pathology, and prove our hypotheses on the basis of pathology. The final goal of our study is to find an imaging marker based on permeability imaging which can assess the distal cerebral collateral circulation quantitatively.

英文关键词： Collateral Circulation;Intracranial Arterial Stenosis;Permeability MR Imaging;Blood-Brain-Barrier