光惰性两亲分子体系中的自组装智能光调控

项目名称： 光惰性两亲分子体系中的自组装智能光调控

项目编号： No.21473005

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 黄建滨

作者单位： 北京大学

项目金额： 100万元

中文摘要： 本课题旨在深入研究光惰性两亲分子体系自组装光调控的基本规律。实现光惰性两亲分子体系中简单、有效、普遍的构筑可逆性光响应有序组合体（如胶束、囊泡、螺旋、纤维等），并拓展这类体系在相关领域中的应用。同时，通过对有序组合体的微观结构及其他性质的表征，了解基本自组装单元与响应性因子之间的相互作用机制。揭示主客体系包结作用等弱相互作用在分子自组装智能调控过程中扮演的角色。了解响应性因子及不同结构表面活性剂与环糊精等大环化合物在包结过程中的热力学结合趋势差异和动力学速度特征；研究几类重要体系在光照、酶（或）pH等多重环境因素影响下的自组装特点，发展多重响应的智能组装体。获得两亲分子自组装智能调控的科学认识。

中文关键词： 光惰性；两亲分子；自组装；光调控；智能

英文摘要： The project will focus on studying the general rules of light active control in light-inert amphiphilic self-assembly systems. We attempt to develop simple, effective and universal approaches to construct self-assemblies (micelle, vesicle, fiber, helix, etc) which can reversibly respond to light irradiation in light-inert amphiphile systems. The applications of such systems in relative areas will also be taken into account. Basing on the research results about the microstructures and other properties of self-assemblies, the interaction mechanism between the self-assembly unit and the responsive unit will be revealed. Moreover, finding out the role of weak intermolecular interactions especially host-guest interaction playing in intelligent regulation and control of molecular self-assembly is also one of the main targets. Through the project, we will make effort to understand the thermodynamic and kinetic characters of the inclusion process between macrocyclic compounds such as cyclodextrin and various guest molecules (amphiphiles with different molecular structures and the molecules acting as responsive unit). Self-assembly features of several important systems under the influence of multiple environmental factors (light and enzyme or light and pH) will be studied into detail so as to develop intelligent self-assembly systems with multiple response. In brief, this project aims to achieve in-depth scientific understanding of intelligent regulation and control of amiphiphilic self-assembly.

英文关键词： light-inert;amphiphile;self-assembly;light-regulated;intelligent