多功能卟啉复合纳米粒子在癌症诊治中的应用研究

项目名称： 多功能卟啉复合纳米粒子在癌症诊治中的应用研究

项目编号： No.81201186

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 影像医学与生物医学工程

项目作者： 梁晓龙

作者单位： 北京大学

项目金额： 23万元

中文摘要： 癌症等重症疾病需要早发现早治疗，先诊断再治疗，而单一的诊断或治疗模式存在延误病情、治疗效果差的缺点，因此研究多功能诊断治疗制剂成为解决这一问题的主要途径。本项目采用溶胶-凝胶法、自组装技术以及共价连接法,将上转换纳米粒子(产生可见光)、富含卟啉衍生物的脂质双层膜（光动力治疗与荧光成像）、化疗药物（化疗）和锰卟啉衍生物（磁共振成像）包埋或修饰到二氧化硅载体表面，构筑集光动力治疗、化疗、磁共振成像和荧光成像多功能于一体的纳米材料，研究该多功能纳米粒子在癌症诊治中的应用。既克服了单一化疗手段的局限性，改善了传统光敏剂水溶性差、易泄漏和自聚集、光穿透深度有限等问题，又可以同时完成癌症的诊断与治疗过程，缩短治疗周期、减轻病人痛苦，为有效治疗癌症和研制新型抗癌材料奠定理论和技术基础。

中文关键词： 癌症；诊断治疗；卟啉；光动力治疗；化疗

英文摘要： Cancer and other severe diseases require early detection and early treatment, first diagnosis and then treatment, modalities of single diagnosis or treatment exist the shortcomings of delaying treatment or poor treatment, so research of multi-functional theranostic agents is to become the main way to solve this problem. This project applied the sol-gel, self-assembly technologies and covalent linkage method, upconversion nanoparticles (to produce visible light), the lipid bilayer membrane with rich porphyrin derivatives (for photodynamic therapy and fluorescence imaging), chemotherapy drugs (for chemotherapy) and manganese porphyrin derivatives (for magnetic resonance imaging) were embedded or modified to the surface of silica carrier to build nanomaterial with multi-functions of photodynamic therapy, chemotherapy, magnetic resonance imaging and fluorescence imaging, the application of such multi-functional nanoparticle in cancer diagnosis and therapy was studied. This research shows many advantages, such as the limitation of single chemotherapy is overcomed, problems with conventional photosensitizers such as poor water solubility, easy-disclosure and self-aggregation, limited optical penetration depth can be effectively improved, cancer diagnosis and treatment process can be simultaneously accomplished, treatm

英文关键词： cancer；theranostic；porphyrin；photodynamic therapy；chemotherapy