基于PET/CT探测器灵敏度特性的呼吸运动伪影校正研究

项目名称： 基于PET/CT探测器灵敏度特性的呼吸运动伪影校正研究

项目编号： No.11265007

项目类型： 地区科学基金项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 贺建峰

作者单位： 昆明理工大学

项目金额： 50万元

中文摘要： PET/CT扫描过程中，患者的呼吸运动成像伪影会影响临床诊断的质量。现有去伪影的方法主要基于图像空间像素估算运动参数，再根据已门控数据校正运动伪影，尚存局限性。本课题拟从新的角度，用探测器灵敏度相关的帧光子数估计呼吸运动参数，再应用于符合事件校正伪影的方法目前尚无报道。本课题预研实验发现，帧光子数序列分布曲线与呼吸运动曲线存在相似性；并观察到随着帧光子序列密度的增加，二者之间的相似性就越高。我们推测帧光子数分布与运动参数关系密切，可用于运动估计校正。为此，课题拟经过蒙特卡罗计算、物理体模测试、动物模型测试和临床数据验证四个环节，深入研究帧光子数分布和运动参数之间的关系。课题组有前期的工作研究积累并发表过相关论文，具备了开展此课题的经验和基础。本课题将为PET/CT成像胸腹部器官呼吸运动伪影校正，探寻一种解决问题的途径。它与传统方法相比，简单速度快,对提高肿瘤患者的早期诊断质量很有意义。

中文关键词： PET/CT；探测器灵敏度；呼吸运动校正；动态数据；图像处理重建

英文摘要： Image degradation caused by patient's respiratory motion in PET/CT imaging may affect clinic diagnosis. The exiting methods for respiratory motion correction are mainly based in the space of reconstructed image to estimate motion parameters by image pixels, and then the estimated parameters can be used to correct motion by gated data, which still has some limitations. The proposed project with the novel method intends to utilize the property of detector geometric sensitivity relating to frame counts to estimate the parameters of respiratory motion, the parameters can be then applied to collected coincidences to correct motion. The idea of the proposed project has not yet been reported on any publication. Some interesting results in our pre-research experiment indicate that the shape of frame count cure is similar with the shape of respiratory motion cure. The evidence that the similarity between the two cures is increasing with the decreasing of interval time among the frames was observed in the pre-research. We suppose that the distribution of frame counts is closely associated with the respiratory parameters. To validate the suppose, the proposed is going through four steps: Monte Carol computation, physical phantom testing, animal model testing, and clinic testing, to deeply study the relationship between the

英文关键词： PET/CT；detector sensitivity；respiratory motion correction；list-mode data；image reconstruction