肺段间平面微视断层解剖研究及三维模型构建

项目名称： 肺段间平面微视断层解剖研究及三维模型构建

项目编号： No.31300983

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 生物科学

项目作者： 左一智

作者单位： 南京医科大学

项目金额： 23万元

中文摘要： 肺段间平面是肺段的边界，也是一种重要的肺间质。它是CT图像中划分肺段的直接标志，也是判断肺内病变位置和范围的重要依据。目前临床缺乏术前精确定位肺段间平面的方法，只能依据它的间接标志（段间静脉）进行肺段划分，其结果常常不准确。我们在前期研究中明确了肺段间平面在正常MSCT图像中的表现，但是研究结果还不系统，同时从微观角度来说，肺段间平面的本质结构是什么？从宏观角度，其三维形态如何？这些问题还不清楚。本研究拟通过组织切片染色、光镜、电镜观察及Micro-CT扫描等方式研究肺段间平面的解剖学本质；通过图像融合技术（Micro-CT与MSCT）深入对肺段间平面在CT图像中的影像学表现的研究；并通过整肺Micro-CT扫描和三维重建技术构建肺段间平面的三维模型。我们的研究将有助于寻找新的显示肺段间平面的影像学方法，明确肺段间平面在影像诊断中的价值，并为胸外科医师提供肺段间平面的三维解剖信息。

中文关键词： 肺段间平面；解剖学；三维；影像学；

英文摘要： Pulmonary intersegmental plane is a layer of interstitial membrane.It serves as the border of two adjacent segments, as well as the direct signal on CT images to outline the range of segments. This structure help the determination of the precise position and range of pulmonary disease within lungs. It is hard to precisely define the direct imaging appearance of intersegmental plane on MSCT. So, doctors often used the indirect landmark of intersegmental plane-intersegmental veins-to outline the border of segment, which was proved to be imperfect. Facing the research background，we were successful in determine the normal MSCT appearance. Although we had some positive findings, this research was still deserved to be improved. In this study, we aimed to: (1) determine the anatomical ture nature of pulmonary intersegmental plane through histology, electronscopy and Micro-CT scanning;(2)improve the previous study on the imaging appearance of intersegmental plane on MSCT through imaging fusion;(3)bulid digital model of intersegmental plane through three-dimensional reconstruction. Our research should be helpful in finding new radiological method to define intersegmental plane. It also might determine the value of intersegmental plane in radiological diagnosis. In addition, it shoud provide the thoracic surgeons with thr

英文关键词： intersegmental plane；anatomy；three-dimensional；radiology；