皮质脑电小波分析定位人脑语言区的方法研究

项目名称： 皮质脑电小波分析定位人脑语言区的方法研究

项目编号： No.81201014

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 神经系统疾病、精神疾病

项目作者： 白红民

作者单位： 广州军区广州总医院

项目金额： 23万元

中文摘要： 我们于2002年在国内首先采用术中直接电刺激在唤醒麻醉下定位脑功能区，旨在保留功能的前提下最大程度的切除病变。实践中发现电刺激费时、会诱发癫痫、出现假阳性和假阴性结果，且无法适合不能配合的病人。研究脑电信号在语言活动时出现的特异性变化规律，使术中脑电图定位脑功能区成为可能。前期研究发现单一频段定位运动区皮层的敏感性93%，特异性84%，提示该方法的可行性及需要完善的内容。本研究拟对大脑手术病人在清醒状态下获取静息和语言任务状态下（数数，命名，阅读和动词联想）皮质脑电信号，皮质直接电刺激确定语言区皮质，利用小波分析方法分析脑电信号，提取单一参数和多维参数及其相应特定阈值，获得皮质脑电定位语言区的特异性参数，建立皮质脑电实时定位语言区皮质新方法，为皮质脑电定位语言区探索新方法。该项目将提高功能区手术中功能区的定位准确性和便利性，提高手术切除质量。

中文关键词： 脑定位；皮质脑电图；语言区皮质；小波分析；

英文摘要： We are the first team in china to employ intraoperative direct electrical stimulation(DES) for mapping of the eloquent areas under awake anaesthesia in 2002 in order to achieve not only maximal but also safe resection of tumors in cerebral eloquent areas. We found that DES provided a real-time, reliable, precise and safe method for brain mapping, but it was time-consuming, epilepsy inducing, resulting in false positive and false negative sometimes. It couldn't be suitable for patients who do not cooperate. To study the specific accurate spectral change of electrocorticography(ECoG) during language processing make it possible to intraoperatively map the language cortices by ECoG. In one of our previous studies, significant u-band change could be detected correctly in 28/30 cases(sensitivity of 93%) with a specificity of 84%. This confirms the the feasibility of this methods and suggest the research directions( improving the sensitivity and specificity). This study will focus on mapping of the language related cortices by ECoG.The ECoG signals of rest-state and performing language tasks(naming, counting, reading and verb generation tasks) are obtained from patient with brain lesions who undergo awake surgery. The language-related cortices were confirmed by DES. The ECoG signals are decomposed and reconstructe

英文关键词： brain mapping；electrocorticography；language related cortex；wavelet analysis；