基于双催化体系不对称合成结构多样性杂环骨架

项目名称： 基于双催化体系不对称合成结构多样性杂环骨架

项目编号： No.21302016

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 韩波

作者单位： 成都中医药大学

项目金额： 25万元

中文摘要： 过去十年中，不对称催化体系的探索与研究取得了丰硕的成果。将两种独立催化体系以合理、有效的方式结合在一起，已发展成为不对称催化的一个重要研究领域。这种双催化的合成策略，能高效地发挥两种不同催化体系各自的优点，实现一些常规反应化学或单一催化体系难以实现的化学转化。该项目结合本课题组前期的部分研究结果，拟围绕两类双催化反应类型：协同（合作）催化模式、串联（接力）催化模式，设计并完成基于三种催化体系（a.有机-金属催化；b.有机-有机催化；c.有机-光氧化还原催化）的不对称反应研究。本项目的成功实施能高立体选择性构建一系列具有合成价值且结构多样性的手性杂环骨架，包括官能团富集的氮杂六元环、氧杂六元环等应用十分广泛的单环结构；以及具有螺环或并环结构的类天然产物（类药物）骨架。

中文关键词： 不对称合成；双催化体系；杂环骨架；；

英文摘要： In the past decade, significant advancement has been achieved in the exploration and investigation of asymmetric catalytic systems. The rational design of a novel dual catalytic system that combines two independent catalytic modes together has become an important research field in asymmetric catalysis. Since the complementary catalysts can perform its own functions, such dual catalytic strategies can enable the discovery of unprecedented transformations, which are not easily realized by using either of the catalytic system alone. Based on our previous works, we will focus on two dual catalytic modes: cooperative (synergistic) pathway, sequential (relay) pathway. Three dual catalytic systems, including organo-metal catalysis, organo-organo catalysis and organo-photoredox catalysis, will be designed and investigated. The whole project will deliver a series of highly enantioenriched heterocyclic scaffolds with skeletal diversity and synthetic usefulness, such as densely functionalized chiral monocyclic structures and spiro-, multi-cyclical nature product-like (drug-like) frameworks.

英文关键词： Asymmetric synthesis；Dual catalytic systems；Heterocyclic scaffolds；；