痰瘀型类风湿性关节炎与淋巴关系的基础研究

项目名称： 痰瘀型类风湿性关节炎与淋巴关系的基础研究

项目编号： No.81330085

项目类型： 重点项目

立项/批准年度： 2014

项目学科： 医药、卫生

项目作者： 施杞

作者单位： 上海中医药大学

项目金额： 290万元

中文摘要： 类风湿关节炎（RA）是以关节病变为主的全身慢性自身免疫性疾病，痰瘀在该病的发生发展中具有重要作用，其粘滞凝涩的特性决定了RA复杂难愈的特点，临床上也缺乏有效的治疗药物。因此，急需深入研究RA痰瘀证发生的生物学基础。.本项目组前期研究观察到RA等炎症关节局部均有淋巴组织的增生，并证明了促进淋巴增生和功能是减轻慢性炎症反应、治疗该类疾病的靶点，临床上采用加味牛蒡子汤逐痰祛瘀治疗RA也取得明显疗效。.基于上述思路和研究基础，本项目将通过临床试验和应用已建立的TNF-Tg炎性关节炎小鼠模型和淋巴体内成像技术，进一步研究痰瘀型关节炎的发病机理、病理变化与淋巴功能之间的相关性，寻找新的治疗靶点；并进一步研究“加味牛蒡子汤”调控Notch 信号通路、血管内皮生长因子C表达及淋巴管功能变化，探讨中医“逐痰祛瘀”与淋巴功能之间的关系，发展中医痰瘀理论。

中文关键词： 痰瘀;类风湿性关节炎;淋巴功能;加味牛蒡子汤;

英文摘要： Rheumatoid arthritis (RA) a systemic autoimmune disease with severe joint lesions. Phlegm and blood stasis play an important part in the RA process, and their characteristic also leads to complexity of RA. There is no effective treatment on RA. Therefore, it is urgent to in-depth study of the biological characteristics of the onset of phlegm and blood stasis. .Our study group observed that lymphangiogenesis in RA and some other inflammatory joint, and proved that promoting lymphangiogenesis and lymphatic function are targets for the treatment of such diseases, and Arctium soup usually achieved significant results..Based on the above ideas and research base, we will further use transgenic mice, using ICG-near infrared, MRI, molecular biology and technology to in-depth study of the regulation effect of lymphatic function on inflammatory arthritis, and explore the effect of Jiawei Arctium soup and its effective component on the regulation of Notch signaling pathway, VEGF-C expression and lymphatic function changes. .Based on the clinical research of phlegm and blood stasis type RA patients, we will explore the relationship between the ZhuTanQuYu law and lymphatic function, discuss the biological basis of the traditional Chinese medicine (TCM) “Phlegm and blood stasis” theory between inflammation and lymphoid hyperplasia and functions, guide the increase of clinical levels and the development of the “phlegm and blood stasis” theory of TCM .

英文关键词： phlegm and blood stasis;Rheumatoid arthritis ;lymphatic function;Jiawei Arctium soup