多级复合孔碳酸钙缓控释抗癌药物载体的可控仿生构筑及其构效关系

项目名称： 多级复合孔碳酸钙缓控释抗癌药物载体的可控仿生构筑及其构效关系

项目编号： No.U1204519

项目类型： 联合基金项目

立项/批准年度： 2013

项目学科： 无机非金属材料学科

项目作者： 马晓明

作者单位： 河南师范大学

项目金额： 31万元

中文摘要： 研究抗癌药物载体的组成、结构及形貌对药物的负载、可控可持续性缓释及靶向传递的影响规律及本质，具有重要的理论意义，是指导合成出具有缓控释性能抗癌药物载体的关键。基于项目组已合成的多孔碳酸钙具有良好的缓控释抗癌药物的性能，本着绿色、简单及可控合成的原则，本项目提出的微孔-介孔-大孔为一体的多级复合孔碳酸钙的抗癌药物载体模型，不仅具有良好的生物相容性及降解性，而且可利用碳酸钙的pH敏感性及其多级复合孔结构，在癌细胞的弱酸性环境下，有望实现选择性传递、大负载量以及逐级可控可持续性缓释药物的效果。经初步实验证明，极具研究前景。基于生物矿化原理，本项目拟选用细胞、蛋白质和糖类为基质，仿生合成多级复合孔碳酸钙微纳米材料。研究影响多级复合孔结构形成的因素及其组装机理，认识材料的结构、性质与药物负载率、体外缓控释放行为及抗肿瘤效果的构效关系。为开发更多种的多级复合孔缓控释药物载体提供理论依据和实验指导。

中文关键词： 仿生合成；生物矿化；多级复合孔；抗癌药物载体；碳酸钙

英文摘要： It is very important to understand the structure-activity relationship between compositions and structures of the anticancer drug carriers and their potential as their controlled/sustained anticancer drug release because it is the key to synthesize an effective controlled/sustained and targeted release drug carrier. To date, inorganic materials as the anticancer drug carriers have attracted great attention duo to the disadvantages of the polymers used in clinic. In this study, CaCO3 materials with hierarchical micro-meso-macroporous structures will be researched as targeted and controlled/sustained release anticancer drug carriers model. CaCO3 materials with hierarchical micro-meso-macroporous structures are the drug carriers with wide development potential and have the advantage of controlled/sustained drug release, which improves drug solubility and stability, enhances efficacy, and reduces toxicity. Firstly, this carrier has good biocompatibility and biodegradability. Secondly, the carriers could possess higher adsorption capacities for anticancer drug and controlled/sustained release anticancer drug because of their large specific surface area and hierarchical micro-meso-macroporous structures. Finally, pH-sensitive of CaCO3 could induce the controlled release of anticancer drug due to the extracellular acid

英文关键词： biomimetic synthesis；biomineralization；micro-meso-macroporous；anticancer drug carriers；calcium carbonate