创伤性脑水肿脱水治疗近红外无损实时疗效评估应用基础研究

项目名称： 创伤性脑水肿脱水治疗近红外无损实时疗效评估应用基础研究

项目编号： No.61275199

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 无线电电子学、电信技术

项目作者： 谢捷如

作者单位： 南京航空航天大学

项目金额： 80万元

中文摘要： 创伤性脑水肿脱水治疗过程的无创实时监测和疗效评估具有重要的临床实用价值。本项目拟采用功能近红外光谱技术（fNIRs）无创实时监测脑水肿脱水治疗时ICP、脑组织局部参数（光学参数、血氧饱和度）等变化规律，建立实时疗效评估模型，达到无损实时疗效评估的目的。主要研究内容：（1）基于fNIRs的人颅脑具有空间位置信息的脑水肿相关组织参数无创测量技术研究；（2）研究ICP与fNIRs测量参数关系，获取ICP近红外无创测试数学模型；（3）研究脑水肿脱水治疗中颅腔内容物的变化规律，从机理上对fNIRs测量参数的空间位置信息进行验证；（4）研究能更有效、更全面反映脱水治疗效果的综合评估因子（包含ICP等常规参数和fNIRs测量参数），同时建立可靠的疗效评估综合模型。本课题旨在探索一种新技术，挖掘新的评估因子，获得疗效评估模型，实现脑水肿脱水治疗无创实时疗效评估。

中文关键词： 创伤性脑水肿；近红外光谱技术；疗效评估；光学参数；关联模型

英文摘要： Noninvasive real-time monitoring dehyration therapy of traumatic brain edema an evaluating the therapeutic efficacy can achive high clinical application value. In the study, noninvasive functional Near Infrared Spectroscopy (fNIRs) technology will be utilized for real-time monitoring dehyration therapy of traumatic brain edema, meanwhile, variation of intracranial pressure (ICP) and local parameters of cerebral tissue (optical parameters, oxygen saturation) with time will be recorded. Model of real-time evaluating therapeutic efficacy will be built and noninvasive real-time evaluating therapeutic efficacy can be realized. The main research contents include: (1) research on noninvasive measurement system with cerebral spatial location by fNIRs in tissue parameters of brain edema; (2) research on the relationship between ICP and fNIRs parameters, obtaining the the mathematical model of noninvasive measuring ICP by fNIRs; (3) research on variation of cerebral contents in dehyration therapy of traumatic brain edema, verification of cerebral spatial location of fNIRs parameters theoretically; (4) research on comprehensive evaluation factors (ICP and fNIRs parameters etc.) which can reflect therapeutic efficacy of dehyration therapy more effectively and entirely, building reliable comprehensive evaluation model of the

英文关键词： traumatic brain edema；Near Infrared Spectroscopy；evaluation of therapeutic efficacy；Optical parameters；relation model