特征选择( Feature Selection )也称特征子集选择( Feature Subset Selection , FSS ),或属性选择( Attribute Selection )。是指从已有的M个特征(Feature)中选择N个特征使得系统的特定指标最优化,是从原始特征中选择出一些最有效特征以降低数据集维度的过程,是提高学习算法性能的一个重要手段,也是模式识别中关键的数据预处理步骤。对于一个学习算法来说,好的学习样本是训练模型的关键。

Clustering with variable selection is a challenging but critical task for modern small-n-large-p data. Existing methods based on Gaussian mixture models or sparse K-means provide solutions to continuous data. With the prevalence of RNA-seq technology and lack of count data modeling for clustering, the current practice is to normalize count expression data into continuous measures and apply existing models with Gaussian assumption. In this paper, we develop a negative binomial mixture model with gene regularization to cluster samples (small $n$) with high-dimensional gene features (large $p$). EM algorithm and Bayesian information criterion are used for inference and determining tuning parameters. The method is compared with sparse Gaussian mixture model and sparse K-means using extensive simulations and two real transcriptomic applications in breast cancer and rat brain studies. The result shows superior performance of the proposed count data model in clustering accuracy, feature selection and biological interpretation by pathway enrichment analysis.

0+
0+
下载
预览
Top