国际组织推荐的儿童和孕妇尿碘标准在我国的适用性研究

项目名称： 国际组织推荐的儿童和孕妇尿碘标准在我国的适用性研究

项目编号： No.81472930

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 刘守军

作者单位： 哈尔滨医科大学

项目金额： 60万元

中文摘要： 本课题拟在12个省农村地区选择3600名孕妇和3600名8-10岁儿童，检测甲状腺容积、血清游离甲状腺素、促甲状腺激素、甲状腺球蛋白、甲状腺球蛋白抗体、尿碘和家中盐碘，评价尿碘浓度100-149μg/L组与150-249μg/L组的孕妇、100-199μg/L组与200-299μg/L组的8-10岁儿童的甲状腺肿大率、亚临床甲状腺功能减退症检出率、甲状腺球蛋白水平和甲状腺球蛋白抗体阳性率，观察孕妇尿碘在100-149μg/L时、8-10岁儿童尿碘在200-299μg/L时是否对人体有害，做出国际组织推荐的尿碘浓度标准是否适合于我国孕妇和8-10岁儿童的结论，为今后碘缺乏病的防治对策提供科学依据。

中文关键词： 碘缺乏病；尿碘；甲状腺功能；甲状腺容积；盐碘

英文摘要： In this study, 3600 pregnant women and 3600 children aged 8-10 years were selected in the countryside in 12 provinces. Thyroid volume, free thyroxin (FT4), thyrotropin (TSH), thyroglobulin (Tg), thyroglobulin antibody (Tg-Ab), urinary iodine level (UI) and iodine concentration in salt was detected.The goitre prevalence (GP), subclinical hypothyroidism rate, the Tg level and the Tg-Ab positive rate was eveluated in the two groups of pregnant women (UI 100-149 μg/L and 150-249 μg/L), and two groups of the children aged 8-10 years (UI 100-199 μg/L and 200-299 μg/L).The risk of adverse health consequences to the body was observed in the pregnant woman whose UI was beween 100 and 149 μg/L and the 8-10 years old children whose UI was beween 200 and 299 μg/L.We expected to make a conclusion that whether the UI level recommended by the international organization is suitable for the pregnant women and the 8-10 year old children in our country, and provide a scientfic evidence for the control measures of the iodine deficiency disorders.

英文关键词： Iodine deficiency disorders;Urinary iodine;Thyroid function;Thyroid volume;Salt iodine