萎胃康颗粒逆转慢性萎缩性胃炎的作用机制研究

项目名称： 萎胃康颗粒逆转慢性萎缩性胃炎的作用机制研究

项目编号： No.81072782

项目类型： 面上项目

立项/批准年度： 2011

项目学科： 轻工业、手工业

项目作者： 赵岩

作者单位： 滨州医学院

项目金额： 10万元

中文摘要： 慢性萎缩性胃炎的产生机理及其逆转机制是胃病研究中的热点和难点问题，探明萎缩性胃炎产生发展变化过程的病理机制，总结萎缩性胃炎产生和逆转的一般规律，寻求逆转萎缩性胃炎的有效方法和药物对萎缩性胃炎的防治，具有重要的临床价值和理论意义。本项目应用SD大白鼠以水杨酸钠灌胃为主等多种刺激制备萎缩性胃炎实验动物模型，观察萎缩性胃炎产生发展变化过程中的病理表现，口服萎胃康颗粒剂进行逆转治疗。采用免疫组化的方法检测PCNA表达、G、D细胞表达和NF-κ#34920;达；胃内EGF和EGFR的表达，从细胞分子生物学水平阐释纯中药制剂萎胃康颗粒逆转慢性萎缩性胃炎的作用机制，探寻能有效逆转萎缩性胃炎的方法和药物，为萎缩性胃炎的科学防治，提供理论依据。

中文关键词： 中药；萎胃康颗粒剂；慢性萎缩性胃炎；逆转；作用机制

英文摘要： The generation mechanism and reversing mechanism of chronic atrophic gastritis are hot spots and difficult problems in the study of gastric disease. It has vital clinical and theoretical significance to prove the pathologic mechanism in the development process of atrophic gastritis, to summary the general rules of generation and reversal of atrophic gastritis and to seek effective methods and drug of reversion,prevention and treatment of atrophic gastritis. This project used SD white rats to make experimental animal model of chronic atrophic gastritis by many kinds of stimulation ,such as primarily filling the stomach using the sodium salicylate.Observe the pathology performance in the development process of atrophic gastritis and carry on the reversal treatment with oral administration of Wei-Wei kang granule. Detect the expression of PCNA ,NF-kB, G and D cell, EGF and EGFR in gastric.Illustrate pure preparations of traditional Chinese medicine Wei-Wei kang granule reversing mechanisms of chronic atrophic gastritis from the level of cell and molecular biology, explore methods and drugs effectively reversing atrophic gastritis and provide theoretical basis for scientific prevention and treatment of atrophic gastritis.

英文关键词： traditional Chinese medicine；Wei-Wei kang granule；chronic atrophic gastritis；revers；mechanism