超支化聚合物/硅的多维、多尺度自组装研究

项目名称： 超支化聚合物/硅的多维、多尺度自组装研究

项目编号： No.20874060

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 化学工业

项目作者： 颜德岳

作者单位： 上海交通大学

项目金额： 40万元

中文摘要： 本项目主要开展了以下两个方面的研究工作：一、功能性超支化聚合物的合成、自组装及应用研究；二、利用超支化聚合物自组装得到的超分子结构为模板来可控制备纳米复合材料。经过三年努力，主要解决了以下科学问题：1）通过功能性超支化聚合物的合成及自组装，得到了球形胶束、蠕虫状胶束、囊泡等超分子结构，发现了超支化聚合物分子结构和组装体形貌之间的内在关系，特别是支化度对自组装结构的影响规律；2）设计合成了新型超支化聚磷酸酯及其衍生物，通过自组装得到了系列具有生物相容性和可降解性的药物输送载体，证明其在生物医药领域具有重要的应用价值；3）以端羧基的超支化缩水甘油为结构导向剂来控制CaCO3的结晶，得到了一系列矿化结构。4）通过超支化聚乙烯亚胺和羧基化的聚二甲基硅氧烷的静电复合制备得到超支化多臂共聚物，并以其为模板原位吸附正硅酸乙酯得到介孔硅材料。上述研究工作对拓展超支化聚合物在自组装和生物矿化领域的应用具有重要的指导意义。相关研究工作在Angew. Chem. Int. Ed, Adv. Mater.等刊物发表论文31篇，其中影响因子3以上论文20篇。

中文关键词： 超支化聚合物；自组装；药物载体；模板；生物矿化；

英文摘要： Two research plans have been perfromed in this project, including the synthesis, self-assembly and biomedical application of hyperbranched polymers, and the applcaition of hyperbranched self-assemblies as the templates to prepare nano composites. Firstly, we had prepared several supramolecular structures, such as spherical micelles,worm-like micelles and vesicles, through the solution self-assembly of amphiphilic hyperbranched polymers, and the relationship between the polymer topological structure and self-assembly strcture was carefully strudied; Secondly, a novel biodegradable and biocompatiable hyperbranched polyphosphate had been synthesized, which could self-assemble into micelles showing great potentials to be advanced drug carriers. Thirdly, a series of CaCO3 crystaline particles had been prepared by using the hyperbranched polymers as the template molecules; Forthly, an amphiphilic supramolecular star-copolymer from anionic monocarboxyl polydimethylsiloxane and cationic hyperbranched polyethyleneimine was prepared via the electrostatic interaction, which works as a soft template to prepare mesoporous silica nanoparticles. All these works have extended the applications of hyperbranched polymers in self-assembly and biomineralization. Up to now, we have published 31 papers for this project in the journals, including Angew. Chem. Int. Ed and Adv. Mater., and the IF factor of twenty papers is higher than 3.

英文关键词： Hyperbranched polymers; self-assembly; drug carriers; template molecules; biomineralization