PEG/双季铵盐类化合物用于制革原料皮防腐的协同作用机理

项目名称： PEG/双季铵盐类化合物用于制革原料皮防腐的协同作用机理

项目编号： No.21476148

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 有机化学

项目作者： 林炜

作者单位： 四川大学

项目金额： 90万元

中文摘要： 本项目将开展PEG/双季铵盐类化合物结合用于制革原料皮防腐的协同作用机理及关键因素研究。首先制备联接基和疏水链均含酯基的可生物降解双季铵盐抗菌化合物，研究分子结构、表面活性与抗菌性能的关系；将优选化合物与具有抑菌功能的PEG结合用于生皮防腐，利用FT-IR、Micro-DSC、AFM、SEM、荧光光谱、Raman光谱、QCM-D、SPR等研究对生皮组织形态结构的影响及与皮胶原蛋白的相互作用，弄清PEG和双季铵盐在抗菌防腐功能上的有效匹配与互补及二者协同作用机理；同时结合色谱分析技术等评价在制革废水中的残留和生物降解性及对鞣革性能的影响。通过对抗菌防腐关键因素的研究，建立起PEG与双季铵盐类化合物协同防腐方法，揭示防腐体系分子构效与相互作用对蛋白抗菌性能影响的一般规律性，为研发新型环境友好的制革原皮防腐材料和应用技术提供可靠的理论依据，并为生物、材料等相关学科领域的研究提供有价值的信息。

中文关键词： 原料皮防腐；PEG；双季铵盐；作用机理；皮革化学品

英文摘要： The synergetic mechanism of polyethylene glycol (PEG) and bis-quaternary ammonium compounds (bis-QACs) in the preservation of raw hides and skins for leather-making will be investigated in this project. We will firstly synthesize biodegradable bis-QACs with the introduction of the ester groups both in the linkage between the two polar heads and in the hydrophobic chains. Their surface active properties and bactericidal properties will be tested and related to their molecular structures. The optimum bis-quaternary ammonium salts, in the combination of PEG with antimicrobial property as proved, will be applied in the raw hide preservation. We will mainly use fourier transform infrared spectroscopy (FTIR), micro-differential scanning calorimetry (Micro-DSC), atomic force microscopy (AFM), scanning electronic microscopy (SEM), fluorescence spectrum, Raman spectrum, quartz crystal microbalance with dissipation (QCM-D) and surface plasmon resonance (SPR) to investigate the influence of the antibacterial agents on the hide tissue structure and the collagen molecules, so as to explore the functional matching and complementary between PEG and the bis-quaternary ammonium salts, i.e, the synergetic antimicrobial effects. By studying the key issues in the hide preservation, we will establish the preservation method by using PEG/bis-quaternary ammonium salts, and reveal the relationships between molecular structure-function, interactions and antimicrobial properties. We are convinced that the results would most benefit to develop environmental friendly preservation materials and applied technologies for leather-making industry, and will also provide valuable information to the related biological and material research fields.

英文关键词： preservation of raw hides and skins;polyethylene glycol;bis-quaternary ammonium compounds;synergetic mechanism;leather chemicals