顺磁性金属离子掺杂的双功能CuInS2纳米晶的合成及性质研究

项目名称： 顺磁性金属离子掺杂的双功能CuInS2纳米晶的合成及性质研究

项目编号： No.51202283

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 无机非金属材料学科

项目作者： 邹彧

作者单位： 中国科学院苏州纳米技术与纳米仿生研究所

项目金额： 25万元

中文摘要： Gd3+，Mn2+等顺磁金属离子的掺杂使得半导体纳米晶同时具有荧光和磁性，可以作为同时应用于荧光成像和核磁共振成像造影的双功能生物探针。但是已经制备出来的掺杂型双功能生物探针往往有毒或者不稳定，不符合实际应用的要求。为此，本项目提出单源前驱体热分解以及后续磷脂包覆相转移的方法制备水溶性顺磁金属离子掺杂的CuInS2纳米晶用作双功能生物探针，这种纳米晶性能稳定且低毒，而且荧光可调至近红外波段，更加有利于深度检测。目前半导体纳米晶的掺杂仍然非常困难，单源前驱体热分解法有利于在保留纳米晶荧光性质的前提下，将顺磁性金属离子掺入CuInS2纳米晶中，实现其双功能。项目主要通过研究不同的合成条件和相转移条件对顺磁性金属离子掺杂的CuInS2纳米晶的荧光和核磁共振成像造影性质的影响，优化这种双功能纳米晶，为其应用奠定基础。

中文关键词： 量子点；硫铟铜；掺杂；生物成像；双功能

英文摘要： Doping with paramagnetic metal ions such as Gd3+ or Mn2+ makes semiconductor nanocrystals luminescent and magnetic, suitable for bifunctional bioprobes acting as luminescent labels of photoluminescence imaging (PI) and contrast agents of magnetic resonance imaging (MRI) at the same time. However, such bioprobes which have been prepared up to now are either toxic or unstable, and can't meet the requirements of practical applications. To overcome these problems, we suggest the use of water-soluble paramagnetic metal ions doped CuInS2 nanocrystals prepared by thermal decomposition of single-source precursor and subsequent phase transfer assisted by phospholipid micelles. CuInS2 nanocrystals are low-toxic and stable. Moreover, the wavelength of their emission can be tuned to near infrared, which is advantageous for in-depth detection. Doping semiconductor nanocrystals is still a big challenge. The method of thermolysis of single-source precursor is effective to dope semiconductor nanocrystals with paramagnetic metal ions while their fluorescence is retained. To optimize the function of nanocrystals and lay a foundation for their application, the effects of different conditions of synthesis and phase transfer on the properties of the doped CuInS2 nanocrystals including photoluminescence and enhancement of MRI signals

英文关键词： quantum dot；CuInS2；doping；bioimaging；bifunctional