重庆市城市化进程中男性精液质量改变及其影响因素的初探

项目名称： 重庆市城市化进程中男性精液质量改变及其影响因素的初探

项目编号： No.81202276

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 预防医学、地方病学、职业病学、放射医学

项目作者： 杨桓

作者单位： 中国人民解放军第三军医大学

项目金额： 23万元

中文摘要： 我室前期在国家自然基金重点项目和重庆市科技攻关项目资助的研究中发现，重庆地区人群精液质量下降显著，且城市居民精液质量下降较农村更大，二者之间存在显著差异。值得关注的是那些居住在中度城市化地区的男性，精液质量下降更为显著。城市化(Urbanization)是人类社会发展的必然规律,但城市化也带来某些危害人体健康的因素，目前尚未见到针对城市化进程中人群精液质量变化情况及其影响因素展开的系统研究。本研究拟在我室前期工作基础上，选取居住于不同城市化程度地区的男性人群，通过现况研究进行流行病学调查，检测水、空气、食物中污染物水平及人体样本相关指标，探求城市化进程中男性精液质量的变化规律，并综合分析环境、社会-心理-行为等因素对精液质量的影响，寻找在城市化进程中，可能对男性生殖能力产生影响的因素，为进一步研究人体生殖功能衰退的机制提供线索，为城市建设中实行人群干预、制定相关措施提供科学理论依据。

中文关键词： 城镇化进程；精液质量；现场流行病学；生活方式；心理因素

英文摘要： Our previous research supported by the State Key Program of National Natural Science of China and Chongqing Science and Technology R&D Program revealed a dramatic drop in semen quality among Chongqing males, and this drop was significantly heavier in urban populations compared with that in rural populations. The males live in areas at medium urbanization need to be paid more attention to as they showed the most decrease in semen quality. As an natural law, human society development leads to urbanization. But hazards, harming human body as well as the male reproduction, are generated in this procedure. However, the harmful factors hidden in urbanization have not yet been studied systematically. Based on our previous research, this study aims to recruit people from areas of different urbanization progresses, 1. By deploying cross-sectional research, detection and measuring pollutants in water, air and food, along with analyzing biological and biochemistry parameters in human specimens, to explore the rule for semen quality change during urbanization; 2. By synthetically analysis of environment, social-psychological-behavioral factors, to: 1) look into the causes embedded in urbanization that lead to the drop of semen quality, 2) provide clues for research in mechanisms of reproduction decay, 3) provide scientific

英文关键词： urbanization；semen quality；field epidemiology；lifestyles；pyschological factors