知识库(Knowledge Base)是知识工程中结构化,易操作,易利用,全面有组织的知识集群,是针对某一(或某些)领域问题求解的需要,采用某种(或若干)知识表示方式在计算 机存储器中 存储、组织、管理和使用的互相联系的知识片集合。这些知识片包括与领域相关的理论知识、事实数据,由专家经验得到的启发式知识,如某领域内有关的定义、定 理和运算法则以及常识性知识等。

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特定领域的知识库(KB)从各种数据源精心整理而来,为专业人员提供了宝贵的参阅咨询。由于自然语言理解和人工智能的最新进展,会话系统使这些KBs很容易被专业人员访问,并且越来越受欢迎。尽管在开放域应用程序中越来越多地使用各种会话系统,但特定于域的会话系统的需求是完全不同的,而且具有挑战性。在本文中,我们针对特定领域的KBs提出了一个基于本体的对话系统。特别是,我们利用领域本体中固有的领域知识来识别用户意图,并利用相应的实体来引导对话空间。我们结合了来自领域专家的反馈来进一步细化这些模式,并使用它们为会话模型生成训练样本,减轻了会话设计人员的沉重负担。我们已经将我们的创新集成到一个对话代理中,该代理关注医疗保健,这是IBM Micromedex产品的一个特性。

https://dl.acm.org/doi/abs/10.1145/3318464.3386139

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Antibodies are widely used reagents to test for expression of proteins and other antigens. However, they might not always reliably produce results when they do not specifically bind to the target proteins that their providers designed them for, leading to unreliable research results. While many proposals have been developed to deal with the problem of antibody specificity, it is still challenging to cover the millions of antibodies that are available to researchers. In this study, we investigate the feasibility of automatically generating alerts to users of problematic antibodies by extracting statements about antibody specificity reported in the literature. The extracted alerts can be used to construct an "Antibody Watch" knowledge base containing supporting statements of problematic antibodies. We developed a deep neural network system and tested its performance with a corpus of more than two thousand articles that reported uses of antibodies. We divided the problem into two tasks. Given an input article, the first task is to identify snippets about antibody specificity and classify if the snippets report that any antibody exhibits non-specificity, and thus is problematic. The second task is to link each of these snippets to one or more antibodies mentioned in the snippet. The experimental evaluation shows that our system can accurately perform both classification and linking tasks with weighted F-scores over 0.925 and 0.923, respectively, and 0.914 overall when combined to complete the joint task. We leveraged Research Resource Identifiers (RRID) to precisely identify antibodies linked to the extracted specificity snippets. The result shows that it is feasible to construct a reliable knowledge base about problematic antibodies by text mining.

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