The emergence and progression of multiple chronic conditions (MCC) over time often form a dynamic network that depends on patient's modifiable risk factors and their interaction with non-modifiable risk factors and existing conditions. Continuous time Bayesian networks (CTBNs) are effective methods for modeling the complex network of MCC relationships over time. However, CTBNs are not able to effectively formulate the dynamic impact of patient's modifiable risk factors on the emergence and progression of MCC. Considering a functional CTBN (FCTBN) to represent the underlying structure of the MCC relationships with respect to individuals' risk factors and existing conditions, we propose a nonlinear state-space model based on Extended Kalman filter (EKF) to capture the dynamics of the patients' modifiable risk factors and existing conditions on the MCC evolution over time. We also develop a tensor control chart to dynamically monitor the effect of changes in the modifiable risk factors of individual patients on the risk of new chronic conditions emergence. We validate the proposed approach based on a combination of simulation and real data from a dataset of 385 patients from Cameron County Hispanic Cohort (CCHC) over multiple years. The dataset examines the emergence of 5 chronic conditions (Diabetes, Obesity, Cognitive Impairment, Hyperlipidemia, and Hypertension) based on 4 modifiable risk factors representing lifestyle behaviors (Diet, Exercise, Smoking Habit, and Drinking Habit) and 3 non-modifiable risk factors, including demographic information (Age, Gender, Education). The results demonstrate the effectiveness of the proposed methodology for dynamic prediction and monitoring of the risk of MCC emergence in individual patients.

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ACM/IEEE第23届模型驱动工程语言和系统国际会议，是模型驱动软件和系统工程的首要会议系列，由ACM-SIGSOFT和IEEE-TCSE支持组织。自1998年以来，模型涵盖了建模的各个方面，从语言和方法到工具和应用程序。模特的参加者来自不同的背景，包括研究人员、学者、工程师和工业专业人士。MODELS 2019是一个论坛，参与者可以围绕建模和模型驱动的软件和系统交流前沿研究成果和创新实践经验。今年的版本将为建模社区提供进一步推进建模基础的机会，并在网络物理系统、嵌入式系统、社会技术系统、云计算、大数据、机器学习、安全、开源等新兴领域提出建模的创新应用以及可持续性。 官网链接：http://www.modelsconference.org/

Background: An early diagnosis together with an accurate disease progression monitoring of multiple sclerosis is an important component of successful disease management. Prior studies have established that multiple sclerosis is correlated with speech discrepancies. Early research using objective acoustic measurements has discovered measurable dysarthria. Objective: To determine the potential clinical utility of machine learning and deep learning/AI approaches for the aiding of diagnosis, biomarker extraction and progression monitoring of multiple sclerosis using speech recordings. Methods: A corpus of 65 MS-positive and 66 healthy individuals reading the same text aloud was used for targeted acoustic feature extraction utilizing automatic phoneme segmentation. A series of binary classification models was trained, tuned, and evaluated regarding their Accuracy and area-under-curve. Results: The Random Forest model performed best, achieving an Accuracy of 0.82 on the validation dataset and an area-under-curve of 0.76 across 5 k-fold cycles on the training dataset. 5 out of 7 acoustic features were statistically significant. Conclusion: Machine learning and artificial intelligence in automatic analyses of voice recordings for aiding MS diagnosis and progression tracking seems promising. Further clinical validation of these methods and their mapping onto multiple sclerosis progression is needed, as well as a validating utility for English-speaking populations.

We investigate the problem of discovering and modeling regime shifts in an ecosystem comprising multiple time series known as co-evolving time series. Regime shifts refer to the changing behaviors exhibited by series at different time intervals. Learning these changing behaviors is a key step toward time series forecasting. While advances have been made, existing methods suffer from one or more of the following shortcomings: (1) failure to take relationships between time series into consideration for discovering regimes in multiple time series; (2) lack of an effective approach that models time-dependent behaviors exhibited by series; (3) difficulties in handling data discontinuities which may be informative. Most of the existing methods are unable to handle all of these three issues in a unified framework. This, therefore, motivates our effort to devise a principled approach for modeling interactions and time-dependency in co-evolving time series. Specifically, we model an ecosystem of multiple time series by summarizing the heavy ensemble of time series into a lighter and more meaningful structure called a \textit{mapping grid}. By using the mapping grid, our model first learns time series behavioral dependencies through a dynamic network representation, then learns the regime transition mechanism via a full time-dependent Cox regression model. The originality of our approach lies in modeling interactions between time series in regime identification and in modeling time-dependent regime transition probabilities, usually assumed to be static in existing work.

As the relative power, performance, and area (PPA) impact of embedded memories continues to grow, proper parameterization of each of the thousands of memories on a chip is essential. When the parameters of all memories of a product are optimized together as part of a single system, better trade-offs may be achieved than if the same memories were optimized in isolation. However, challenges such as a sparse solution space, conflicting objectives, and computationally expensive PPA estimation impede the application of common optimization heuristics. We show how the memory system optimization problem can be solved through computational intelligence. We apply a Pareto-based Differential Evolution to ensure unbiased optimization of multiple PPA objectives. To ensure efficient exploration of a sparse solution space, we repair individuals to yield feasible parameterizations. PPA is estimated efficiently in large batches by pre-trained regression neural networks. Our framework enables the system optimization of thousands of memories while keeping a small resource footprint. Evaluating our method on a tractable system, we find that our method finds diverse solutions which exhibit less than 0.5% distance from known global optima.

We show that if a permutation statistic can be written as a linear combination of bivincular patterns, then its moments can be expressed as a linear combination of factorials with constant coefficients. This generalizes a result of Zeilberger. We use an approach of Chern, Diaconis, Kane and Rhoades, previously applied on set partitions and matchings. In addition, we give a new proof of the central limit theorem (CLT) for the number of occurrences of classical patterns, which uses a lemma of Burstein and Hasto. We give a simple interpretation of this lemma and an analogous lemma that would imply the CLT for the number of occurrences of any vincular pattern. Furthermore, we obtain explicit formulas for the moments of the descents and the minimal descents statistics. The latter is used to give a new direct proof of the fact that we do not necessarily have asymptotic normality of the number of pattern occurrences in the case of bivincular patterns. Closed forms for some of the higher moments of several popular statistics on permutations are also obtained.

This paper studies decentralized federated learning algorithms in wireless IoT networks. The traditional parameter server architecture for federated learning faces some problems such as low fault tolerance, large communication overhead and inaccessibility of private data. To solve these problems, we propose a Decentralized-Wireless-Federated-Learning algorithm called DWFL. The algorithm works in a system where the workers are organized in a peer-to-peer and server-less manner, and the workers exchange their privacy preserving data with the anolog transmission scheme over wireless channels in parallel. With rigorous analysis, we show that DWFL satisfies $(\epsilon,\delta)$-differential privacy and the privacy budget per worker scale as $\mathcal{O}(\frac{1}{\sqrt{N}})$, in contrast with the constant budget in the orthogonal transmission approach. Furthermore, DWFL converges at the same rate of $\sqrt{\frac{1}{TN}}$ as the best known centralized algorithm with a central parameter server. Extensive experiments demonstrate that our algorithm DWFL also performs well in real settings.

In this study, we develop an asymptotic theory of nonparametric regression for a locally stationary functional time series. First, we introduce the notion of a locally stationary functional time series (LSFTS) that takes values in a semi-metric space. Then, we propose a nonparametric model for LSFTS with a regression function that changes smoothly over time. We establish the uniform convergence rates of a class of kernel estimators, the Nadaraya-Watson (NW) estimator of the regression function, and a central limit theorem of the NW estimator.

The estimation from available data of parameters governing epidemics is a major challenge. In addition to usual issues (data often incomplete and noisy), epidemics of the same nature may be observed in several places or over different periods. The resulting possible inter-epidemic variability is rarely explicitly considered. Here, we propose to tackle multiple epidemics through a unique model incorporating a stochastic representation for each epidemic and to jointly estimate its parameters from noisy and partial observations. By building on a previous work, a Gaussian state-space model is extended to a model with mixed effects on the parameters describing simultaneously several epidemics and their observation process. An appropriate inference method is developed, by coupling the SAEM algorithm with Kalman-type filtering. Its performances are investigated on SIR simulated data. Our method outperforms an inference method separately processing each dataset. An application to SEIR influenza outbreaks in France over several years using incidence data is also carried out, by proposing a new version of the filtering algorithm. Parameter estimations highlight a non-negligible variability between influenza seasons, both in transmission and case reporting. The main contribution of our study is to rigorously and explicitly account for the inter-epidemic variability between multiple outbreaks, both from the viewpoint of modeling and inference.

In this paper, we study the probabilistic stability analysis of a subclass of stochastic hybrid systems, called the Planar Probabilistic Piecewise Constant Derivative Systems (Planar PPCD), where the continuous dynamics is deterministic, constant rate and planar, the discrete switching between the modes is probabilistic and happens at boundary of the invariant regions, and the continuous states are not reset during switching. These aptly model piecewise linear behaviors of planar robots. Our main result is an exact algorithm for deciding absolute and almost sure stability of Planar PPCD under some mild assumptions on mutual reachability between the states and the presence of non-zero probability self-loops. Our main idea is to reduce the stability problems on planar PPCD into corresponding problems on Discrete Time Markov Chains with edge weights. Our experimental results on planar robots with faulty angle actuator demonstrate the practical feasibility of this approach.

Self-training algorithms, which train a model to fit pseudolabels predicted by another previously-learned model, have been very successful for learning with unlabeled data using neural networks. However, the current theoretical understanding of self-training only applies to linear models. This work provides a unified theoretical analysis of self-training with deep networks for semi-supervised learning, unsupervised domain adaptation, and unsupervised learning. At the core of our analysis is a simple but realistic expansion'' assumption, which states that a low-probability subset of the data must expand to a neighborhood with large probability relative to the subset. We also assume that neighborhoods of examples in different classes have minimal overlap. We prove that under these assumptions, the minimizers of population objectives based on self-training and input-consistency regularization will achieve high accuracy with respect to ground-truth labels. By using off-the-shelf generalization bounds, we immediately convert this result to sample complexity guarantees for neural nets that are polynomial in the margin and Lipschitzness. Our results help explain the empirical successes of recently proposed self-training algorithms which use input consistency regularization.

This paper focuses on the expected difference in borrower's repayment when there is a change in the lender's credit decisions. Classical estimators overlook the confounding effects and hence the estimation error can be magnificent. As such, we propose another approach to construct the estimators such that the error can be greatly reduced. The proposed estimators are shown to be unbiased, consistent, and robust through a combination of theoretical analysis and numerical testing. Moreover, we compare the power of estimating the causal quantities between the classical estimators and the proposed estimators. The comparison is tested across a wide range of models, including linear regression models, tree-based models, and neural network-based models, under different simulated datasets that exhibit different levels of causality, different degrees of nonlinearity, and different distributional properties. Most importantly, we apply our approaches to a large observational dataset provided by a global technology firm that operates in both the e-commerce and the lending business. We find that the relative reduction of estimation error is strikingly substantial if the causal effects are accounted for correctly.

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