The DNA sequencing is the process of identifying the exact order of nucleotides within a given DNA molecule. The new portable and relatively inexpensive DNA sequencers, such as Oxford Nanopore MinION, have the potential to move DNA sequencing outside of laboratory, leading to faster and more accessible DNA-based diagnostics. However, portable DNA sequencing and analysis are challenging for mobile systems, owing to high data throughputs and computationally intensive processing performed in environments with unreliable connectivity and power. In this paper, we provide an analysis of the challenges that mobile systems and mobile computing must address to maximize the potential of portable DNA sequencing, and in situ DNA analysis. We explain the DNA sequencing process and highlight the main differences between traditional and portable DNA sequencing in the context of the actual and envisioned applications. We look at the identified challenges from the perspective of both algorithms and systems design, showing the need for careful co-design.
翻译:DNA测序是确定某一DNA分子内核核素确切顺序的过程。新的便携式和相对廉价的DNA测序器,如牛津南奥波尔Minion等,有可能将DNA测序移出实验室之外,从而导致更快和更容易获得DNA诊断;然而,便携式DNA测序和分析对移动系统来说具有挑战性,因为数据输送量高,在连接和功率不可靠的环境中进行计算密集处理。本文分析了移动系统和移动计算必须应对的挑战,以最大限度地发挥便携式DNA测序的潜力,并进行现场DNA分析。我们解释DNA测序过程,并结合实际应用和设想应用,突出传统和便携式DNA测序之间的主要差异。我们从算法和系统设计的角度审视已查明的挑战,表明需要谨慎地共同设计。